Microdosing to treat PMDD
Microdosing to treat PMDD. While there’s a common trope of women being irritable, weepy, or otherwise moody while they’re on their period, the difficulty lies before the bleeding starts for most women who experience emotional symptoms in their cycle. Many women are turning to microdosing to treat PMDD. The P in PMS stands for premenstrual. A menstrual cycle is divided into four phases: menstruation (the bleeding phase or what most people call “the period”), the follicular phase (from menstruation until ovulation), ovulation (around day 14), and the luteal phase. The entire process lasts around 28 days, although some women may have shorter or longer cycles.
Premenstrual Dysphoric Disorder takes PMS and cranks it up 100 degrees. Impatience can become irritability or rage that lasts for days, and sadness may turn into depression and suicidal thoughts. Anxiety, insecurity, fatigue, tender breasts, trouble concentrating, sleep problems, and food cravings are all common. These symptoms may last the entire two weeks of the luteal phase, from ovulation until bleeding begins. People who struggle with PMDD tend to count down the days until they start bleeding. After which they usually start to feel relief. Many say that they feel they only have one good week in the month, and everything feels like it goes downhill rapidly right after ovulation.
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Why more women are turning to microdosing
The PMDD subreddit has 40.8k members at the time of writing. There, people who get periods and partners of those who get periods write about the challenges they face and support each other through “hell week”, This is the week leading up to their period, during the luteal phase. “Does anyone else want to break up with their partner each month during their luteal period?” “I can’t do this anymore” “Counting down the days until I get my period.”
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Many struggle to find a doctor who can take their symptoms seriously
Studies suggest that while between 3% and 8% of women meet the entirety of the criteria for a PMDD diagnosis, 75% of women experience some PMS symptoms. 13-18% of women may experience severe enough PMS symptoms to cause impairment or distress.
Many struggle to find a doctor who can take their symptoms seriously. And even when they do, they often spend months or years trying different types of birth control and antidepressants. Often, they find no relief, only side effects such as decreased libido and weight gain. Or they find that their symptoms get worse or their emotions feel blunted. They may experience less depression and anxiety, but they find their capacity for joy reduced. Haus of utopia online.
Is microdosing effective for PMDD?
The practice of microdosing is taking tiny doses of a psychedelic substance, such as 1/10th or 1/20th of a regular dose. Microdosers usually take a dose every few days or use a schedule such as taking the microdose for four days, and then taking a three-day break. Because the amount is minimal, users don’t experience the typical effects associated with psychedelics, like hallucinations or changes in perception. Instead, they report feeling slightly better: more creative, joyous, or focused. Psilocybin microdosers often “stack” their dose with other medicinal mushrooms or supplements, such as Lion’s Mane, which is anti-inflammatory and reported to have benefits in reducing anxiety and depression.
While it’s difficult to find studies on the effects of microdosing on PMDD, the research on microdosing in general can help us understand why it seems to help. Microdosers scored lower on negative emotionality and reported reduced anxiety and enhanced sociality
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Why microdosing may help PMDD symptoms
The serotonergic system, which is closely reciprocal with the gonadal hormones, has been identified as “the most plausible target of intervention” in PMDD. SSRIs are the current preferred conventional treatment, often given only in the luteal phase. Serotonin is involved in most reported PMDD symptoms, such as anger and irritability, depressive symptoms, and specific food cravings.
While SSRIs may provide relief for the emotional symptoms of PMDD, they usually don’t offer much for the pain of physical symptoms. Possible side effects of SSRIs include agitation, insomnia, headache, and an impact on appetite, which can worsen regular PMS and PMDD symptoms. On rare occasions, SSRIs can also cause serotonin syndrome.
How psilocybin works on the serotonergic system
Like most commonly prescribed antidepressants today, psilocybin works on the serotonergic system.  Common antidepressant SSRIs (selective serotonin reuptake inhibitors) do as the name suggests and inhibit the reupdate of serotonin in the neuron synapses, making the serotonin “hang out” for longer. Meanwhile, psilocybin is chemically similar to serotonin and binds to serotonin receptors in the brain. Thus, it can make your brain think there is more serotonin in your system than there is without playing with the serotonin levels. And while SSRIs may take up to two weeks for one to feel effects, one feels the effect of microdosing within a couple of hours, and the healing effects can last months.
Women are turning to microdosing to treat PMDD
A drug that can help with both the physical and emotional aspects of PMDD with no extreme side effects such as insomnia or sexual dysfunctional sounds like a dream. Yet microdosing seems to deliver all these effects and provide PMDD sufferers with increased quality of life. Yet that’s not the only remarkable thing. While SSRIs tend to work only when you use them on a daily basis, studies suggest that psychedelics such as psilocybin mushrooms increase long-term neuroplasticity and can help patients make long-lasting changes.
Hopefully we will see more research on the effects of microdosing psilocybin mushrooms for PMDD and other debilitating mental health disorders soon. Ideally, once the research becomes unavoidable it will pave the way to easier access so that everyone struggling with PMDD and other related mental health challenges may be empowered to choose their treatment options. Many women are already women are turning to microdosing to treat PMDD but the number will keep increasing as more research becomes available.
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In the meantime, there are solutions if you’re looking to buy psychedelics online in Canada. Utopia Mushroom Co. is a trusted magic mushroom dispensary in Canada that offers lab-tested microdose capsules with 50 and 100mg of Golden Teacher magic mushrooms, coupled with locally grown functional mushrooms such as Lions Mane and Reishi for additional nootropic and adaptogenic support. There’s no need to suffer with PMDD symptoms such as fatigue and mood swings in silence anymore, microdosing mushrooms may provide you with relief.